Promethazine is metabolized by the liver to a range of compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites appearing while in the urine.
Excessively big dosages of antihistamines, which include promethazine hydrochloride, in pediatric individuals may possibly lead to unexpected death (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric patients that are acutely ill related to dehydration, There's a heightened susceptibility to dystonias with the use of promethazine HCl.
Antihistamines and codeine are each contraindicated to be used while in the cure of lessen respiratory tract signs and symptoms, which includes asthma.
Instruct nursing mothers to speak to the child’s health practitioner promptly should they observe these symptoms and, if they cannot reach the health care provider instantly, to go ahead and take baby to an unexpected emergency room or call 911 (or area crisis solutions).
For preoperative medication kids call for doses of 0.5 mg for each pound of overall body pounds together having an properly lowered dose of narcotic or barbiturate and the right dose of an atropine-like drug.
Absorption Codeine is absorbed within the gastrointestinal tract with most plasma concentration occurring sixty minutes publish administration. The existence of a significant-Excess fat, high-calorie meal didn't drastically impact the PK of codeine.
Promethazine HCl and Codeine Phosphate Oral Alternative really should be utilised with caution in clients with bone- marrow depression. Leukopenia and agranulocytosis have been described, typically when promethazine continues to be Employed in association with other recognised marrow-poisonous brokers.
Children Postmarketing scenarios of respiratory melancholy, such as fatalities, are actually documented with use of promethazine in pediatric clients. Concomitant administration with other respiratory depressants might enhance the chance of respiratory despair.
In another study a single 100-mg/kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification in the offspring.
The subsequent laboratory checks can be influenced in sufferers who're receiving therapy with promethazine HCl:
Significant respiration challenges. Promethazine HCl Oral Alternative really should website not be Utilized in individuals with very poor lung functionality for instance Persistent obstructive lung condition or respiratory difficulties while sleeping (slumber apnea.)
Overdose of codeine in Older people is connected with deadly respiratory depression, and using codeine in youngsters more youthful than 12 yrs of age has actually been connected with fatal respiratory melancholy when applied as advised [see Warnings and Precautions (five.
Clearance may very well be diminished along with the metabolites could accumulate to Significantly greater plasma levels in patients with renal failure as compared with sufferers with normal renal functionality.
Antihistamines are contraindicated to be used while in the remedy of reduced respiratory tract signs or symptoms including bronchial asthma.